Two Cases of Metronidazole-induced Encephalopathy / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 195-200, 2005.
Article
in Ko
| WPRIM
| ID: wpr-17264
Responsible library:
WPRO
ABSTRACT
Metronidazole is a 5-nitroimidazole compound known as an antimicrobial agent widely used for the treatment of protozoal infection, anaerobic infection, Helicobacter pylori infection and hepatic encephalopathy. It may produce a number of neurologic side effects including peripheral neuropathy, seizure, encephalopathy, ataxic gait and dysarthritic speech. There have been ten or more reports of metronidazole-induced encephalopathy in the literatures including a few reports of brain imaging changes by magnetic resonance images (MRI). However, none of the case of metronidazole-induced encephalopathy in patients with hepatic encephalopathy has been reported yet. Recently, we experienced two cases of metronidazole-induced encephalopathy in patients with liver cirrhosis caused by chronic hepatitis B, which were diagnosed by brain MRI and MR spectroscopy. In this report, we present 2 cases of metronidazole-induced encephalopathy with MR imaging and MR spectroscopic changes including follow- up imaging performed after the discontinuation of the metronidazole with a review of the literatures.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Brain Diseases
/
English Abstract
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Magnetic Resonance Imaging
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Magnetic Resonance Spectroscopy
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Metronidazole
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Anti-Infective Agents
Limits:
Female
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Humans
/
Male
Language:
Ko
Journal:
The Korean Journal of Gastroenterology
Year:
2005
Type:
Article